Future Prospects for the Use of Monoclonal Antibodies Research Paper

Future Prospects for the Use of Monoclonal Antibodies - Research Paper Example Later, Behring suggested that active immunity could be produced in humans by a combination of diphtheria toxin and antitoxin serum (Llewelyn, Hawkins, Russell, 1992). However, it was Paul Ehrlich whose work made it possible to produce antiserum to diphtheria toxin on a mass scale. The side chain theory of toxicity was proposed by Ehrlich, according to which, â€Å"toxins mediated their effects on cells through preformed protein side chains and immunity arose because of overproduction of these side chains† (Llewelyn, Hawkins, Russell, 1992.) Cà ©sar Milstein and Georges Kà ¶hler, in 1975, managed to produce in vitro "custom-built" antibodies. They produced a hybridoma by fusing rodent antibody-producing cells with tumor cells from mice bone marrow. A hybridoma, provided with the correct nutrients, can grow indefinitely and divide to produce monoclonal antibodies (antibodies of a single type), on a large scale (Saldanha, 2000.) Five classes of immunoglobulin (Ig) are found in mammals: IgA, IgD, IgE, IgG, and IgM. In some select mammals, IgG and IgA are further subdivided into subclasses (isotypes) due to polymorphisms in the heavy chain (Lipman et al, 2005). The prototype antibody is IgG, which is a glycoprotein having a molecular weight of 150000 Dalton. The molecule has a Y shaped structure, consisting of two identical heavy chain-light chain heterodimers, that is linked together by a disulfide bridge. While the heavy chain comprises three constant immunoglobulins (Ig) domains and one variable (V) domain, the light chains consist of a single constant Ig domain and a single variable domain. The host defense mechanism is initiated by the antigen binding site (Fab) and the Fc region (fragment crystallizable) site (Llewelyn, Hawkins, Russell, 1992.) In order to effectively bind a wide range of antigens, there are numerous mechanisms which come into play.

The Developing Business Essay Example | Topics and Well Written Essays - 3000 words

The Developing Business - Essay Example 20). Apparently, more corporations are getting aware of the necessities of integrating better corporate governance, improved risk management methods, and sufficient business social, financial, and environmental responsibilities that are a pre-requisite for enhanced sustainability. Commercial firms play a fundamental role in the concept of sustainable development, and this is due to their potential to enhance sustainable development and their deleterious effects on the community and ecosystem. Within the essential role that business firms play to achieve sustainable development, social and environmental responsibility has emerged to concretize the paradigm of sustainable development (Schneider, 2014, p. 526). As aforementioned, the three forms of sustainability remains imperative in the maintenance of both societal and organizational needs. Financial sustainability, for instance, ensures that an organization develops structures that focuses on creating significant profit from investments made. Moreover, financial sustainability must focus on embracing the continuous provision of positive outcomes from investment by developing sustainable long-term objectives. On the contrary, environmental sustainability defines an organization’s initiatives and establishment of the structures aimed at significant reduction of causing effects to the surrounding. A business that focuses on environmental sustainability ensures that its operations and daily activities remain friendly to the environment and do not cause climate change, pollution, or degradation. Such environmental sustainable corporations also contribute towards creation and development of policies and initiatives that would enhance e nvironmental safety. On the contrary, social sustainability entails community or societal initiatives aimed at establishing frameworks that ensure